Lessons from simple marine models on the bacterial regulation of eukaryotic development

Abstract

Molecular cues from environmental bacteria influence important developmental decisions in diverse marine eukaryotes. Yet, relatively little is understood about the mechanisms underlying these interactions, in part because marine ecosystems are dynamic and complex. With the help of simple model systems, including the choanoflagellate Salpingoeca rosetta, we have begun to uncover the bacterial cues that shape eukaryotic development in the ocean. Here, we review how diverse bacterial cues - from lipids to macromolecules - regulate development in marine eukaryotes. It is becoming clear that there are networks of chemical information circulating in the ocean, with both eukaryotes and bacteria acting as nodes; one eukaryote can precisely respond to cues from several diverse environmental bacteria, and a single environmental bacterium can regulate the development of different eukaryotes.\n\nHighlightsO_LICues from environmental bacteria influence the development of many marine eukaryotes\nC_LIO_LIThe molecular cues produced by environmental bacteria are structurally diverse\nC_LIO_LIEukaryotes can respond to many different environmental bacteria\nC_LIO_LISome environmental bacteria act as \"information hubs\" for diverse eukaryotes\nC_LIO_LIExperimentally tractable systems, like the choanoflagellate S. rosetta, promise to reveal molecular mechanisms underlying these interactions\nC_LI