host-pathogen & immune response

Stress-adapted endophytic Pseudomonas strains isolated from unmanaged lupin promote potato growth and suppress verticillium wilt through complementary biocontrol and plant growth-promoting mechanisms

Changes in anterior cingulate connectivity associated with response to antidepressant treatment for major depressive disorder

This study examines changes in anterior cingulate cortex connectivity in response to antidepressant treatment in MDD patients, finding distinct patterns associated with treatment response and remission.

First-in-class -PET radiotracers for GPR39: A platform for noninvasive target engagement imaging in vivo

This paper introduces [18F]GPR39 2.1, a PET radiotracer for noninvasive imaging of GPR39, showing high specificity and sensitivity in vivo.

Polyphosphate metabolism genes are associated with hydroxyapatite biomineralization capacity in a novel hydrogenotrophic methanogen Methanobacterium AMB_03

This study links polyphosphate metabolism genes to hydroxyapatite biomineralization in Methanobacterium AMB_03, showing that polyphosphate synthesis enables carbonate-substituted hydroxyapatite precipitation under phosphate-enriched conditions.

Impaired Fermentation in the Absence of Gut Microbiota Promotes Inulin-Induced Intestinal Inflammation

The paper shows that impaired gut microbiota fermentation of inulin leads to intestinal inflammation in mice, highlighting the importance of microbial metabolism in fiber tolerance.

MmuPV1 and HPV E6 Elevate Nuclear Accumulation of IKK? to Impair NF-κB Signaling to Promote Persistent Infection

This study shows MmuPV1 and HPV16 E6 oncoproteins disrupt NF-κB signaling by increasing nuclear IKKα localization, suggesting a shared mechanism in papillomavirus persistence.

Variable errors suppress implicit motor adaptation among older adults

This study shows that older adults exhibit enhanced implicit motor adaptation only with consistent errors, not variable ones, suggesting error consistency is key for age-related adaptation.

The Src family kinases Lck and Fyn promote transendothelial migration of T cells

This study identifies Lck and Fyn as essential Src family kinases required for T cell transendothelial migration through their regulation of PI3K signaling and cytoskeletal dynamics.

The role of familiarity in grouping decisions of Trinidadian guppies

This study investigates whether Trinidadian guppies prefer to group with familiar individuals, finding no evidence for familiarity preference despite a strong preference for conspecifics.

Enhanced hypoxic ventilatory response is accompanied by a decrease in carotid body mitochondrial oxygen affinity in heart failure

This study investigates changes in carotid body mitochondrial function in heart failure, finding decreased oxygen affinity and increased oxidative stress.

Diverse bacteria exhibit superadditive growth on mixed classes of carbon sources

The paper shows that some bacteria grow better on mixed carbon sources than on individual ones, and links this to their genetic makeup and metabolic preferences.

Interventional breath analysis reveals oral microbial conversion of 1,2-Propanediol into Propanal and 1-Propanol

This study shows that oral exposure to 1,2-propanediol increases exhaled propanal and 1-propanol, suggesting microbial conversion in the mouth.

ATF3 Preserves Macrophage Cholesterol Homeostasis during Metabolic Stress

This study shows ATF3 helps macrophages manage cholesterol during metabolic stress by balancing inflammation and sterol-responsive gene expression.

Effects of Overripe Banana Processing Techniques on the Chemical Composition and Attractancy to Aedes aegypti and Aedes albopictus

This study evaluates how different processing techniques of overripe banana extracts affect their chemical composition and attractiveness to Aedes aegypti and Aedes albopictus mosquitoes.

Serotonin Reuptake Inhibition Reduces NMDAR-Associated Reward Liability Without Compromising Rapid Antidepressant Efficacy

This study shows that combining serotonin reuptake inhibition with NMDAR antagonism reduces reward-related effects while maintaining rapid antidepressant efficacy.

Gregariousness can promote invasion success of pest insects while higher environmental heterogeneity decreases it

This study shows that gregariousness increases survival of pest insects against predators, while higher environmental heterogeneity reduces predation risk.

Disease dynamics during ecosystem restoration and faunal reassembly

This study uses a model to show that disease dynamics during ecosystem restoration depend on pathogen transmissibility, timing of slow life history species establishment, and community assembly, not just biodiversity.

Reversible decrease in swimming motility accompanies emergent β-lactam antibiotic resistance in Escherichia coli

This study shows that reduced swimming motility accompanies B-lactam antibiotic resistance in E. coli through efflux mechanisms, with motility recovery after antibiotic removal.

Environmental Frass Remodels the Larval Gut Microbiome to Enable Black Soldier Fly (Hermetia illucens) Bioconversion of Livestock Manure

This study shows that wild frass enhances BSFL growth on rabbit manure by introducing lignocellulose-degrading microbes, which are lost in captive-reared frass.

Mitochondrial Dysfunction is Part of a Novel Mechanism for Chemotherapy-Induced Neuropathic Pain

This study identifies persistent spinal mitochondrial dysfunction and increased mPTP susceptibility as features of chemotherapy-induced neuropathic pain and supports mitochondrial protection as a therapeutic strategy.

TMEM11-Dependent Cristae Architecture Restrains Imiquimod-Induced NLRP3 Inflammasome Activation via Mitochondrial ROS

This study shows that TMEM11-dependent cristae architecture limits mtROS production, thereby restraining IMQ-induced NLRP3 inflammasome activation.

The role of Plasmodium falciparum acyl-coenzyme A synthetase 10 in fatty acid acquisition and lipid synthesis

This study investigates the role of Plasmodium falciparum ACS10 in fatty acid acquisition and lipid synthesis during the asexual blood stage, showing its necessity for incorporating specific fatty acids into parasite lipids.

Targeting distinct neuronal populations with AAV vectors reveals neurogenesis-associated anxiolytic effects of JNK inhibition

This study uses AAV vectors to target specific neuronal populations and shows that JNK inhibition has distinct anxiolytic effects depending on the targeted cells.

Integrating bacterial genomics and host transcriptomics links Burkholderia pseudomallei variation to melioidosis mortality and neutrophil responses

Rapid environmental DNA detection with isothermal amplification methods: a comparison with the real-time quantitative PCR in the natterjack toad (Epidalea calamita).

This paper compares isothermal amplification methods (LAMP and RPA) with qPCR for detecting natterjack toad eDNA, finding RPA matches qPCR sensitivity while LAMP is less sensitive.

Structural and functional examination of Neisseria gonorrhoeae TfpC reveals a dynamic two-domain architecture required for type IV pilus function

This study examines the structure and function of Neisseria gonorrhoeae TfpC, revealing its dynamic two-domain architecture essential for type IV pilus function.

Psychoneuroimmunology of Viral Hepatitis and Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

This study conducts a systematic review and meta-analysis of 24 studies to explore the link between viral hepatitis, hepatocellular carcinoma, and neuropsychiatric disorders, identifying immune and inflammatory mechanisms.

Early visual cortex is not functionally necessary for temporal attention: A TMS study

Positive cooperativity enhances coupling of a second G protein to a GPCR dimer

The paper shows that a second G protein couples with higher affinity to a GPCR dimer than the first, due to conformational stabilization by the first G protein.

Mucin promotes pneumococcal colonization via autolysis suppression and tryptophan-mediated immune modulation

This study shows that mucin promotes pneumococcal colonization by suppressing autolysis and modulating immune responses through tryptophan biosynthesis.