Geometry Linked to Untangling Efficiency Reveals Structure and Computation in Neural Populations

Abstract

From an eagle spotting a fish in shimmering water to a scientist extracting patterns from noisy data, many cognitive tasks require untangling overlapping signals. Neural circuits achieve this by transforming complex sensory inputs into distinct, separable representations that guide behavior. Data-visualization techniques convey the geometry of these transformations, and decoding approaches quantify performance efficiency. However, we lack a framework for linking these two key aspects. Here we address this gap by introducing a data-driven analysis framework, which we call Geometry Linked to Untangling Efficiency (GLUE) with manifold capacity theory, that links changes in the geometrical properties of neural activity patterns to representational untangling at the computational level. We applied GLUE to over seven neuroscience datasets--spanning multiple organisms, tasks, and recording techniques--and found that task-relevant representations untangle in many domains, including along the cortical hierarchy, through learning, and over the course of intrinsic neural dynamics. Furthermore, GLUE can characterize the underlying geometric mechanisms of representational untangling, and explain how it facilitates efficient and robust computation. Beyond neuroscience, GLUE provides a powerful framework for quantifying information organization in data-intensive fields such as structural genomics and interpretable AI, where analyzing high-dimensional representations remains a fundamental challenge.