bioRxivCancer BiologyPreprint
Dose response relationships for gamma radiation induced chromosomal instability
Y.A. Eidelman, S.V. Slanina, V.S. Pyatenko, I.K. Khvostunov, S.G. Andreev
Abstract
Different cell lines demonstrate various dose response for radiation-induced chromosomal instability (RICI). To clarify the origin of differences we analyzed own and published data on RICI for four cell lines, V79, TK6, WTK1 and CHO-K1 on the basis of the mechanistic RICI model. We conclude that observable dose-response shapes, both plateau-like and strong dose dependent behavior, may be jointly explained by the same model of RICI. Mechanistic modeling reveals that a variation of certain set of RICI parameters leads to strong modification of dose-response curve.
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