bioRxivGeneticsPreprint
A nearly optimal sequential testing approach to permutation-based association testing
Julian HeckeriD, Ingo RuczinskiiD, Brent A. CoulliD, Christoph LangeiD
Abstract
The following technical report describes the technical details for the implementation of a sequential testing approach to permutation-based association testing in whole-genome sequencing studies. The sequential testing approach enables to control the probability of a type 1 and type 2 error at arbitrary small pre-specified levels and approaches the theoretical minimum of expected number of required permutations as these levels go to zero.
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