Scott Hazelhurst

This paper describes a study on participant engagement and feedback in microbiome projects in Africa, finding that culturally appropriate and timely feedback can improve trust and motivate health behaviors.

The paper develops pathway-specific polygenic risk scores for hypertension in a West African cohort, finding improved predictive power compared to baseline models.

The paper examines how geography, ancestry, age, and sex influence the prevalence of somatic autosomal mosaic chromosomal alterations in blood across diverse populations.

This study expands the human gut microbiome atlas of Africa by analyzing 1,803 women from four countries, revealing geographic and lifestyle-associated taxa and novel microbial genomes.

This paper presents an FPGA-based tool for accelerating GWAS permutation testing, achieving significant speed improvements over CPU-based methods like PLINK.

This paper presents a blood regulatory variation map from Southern African populations, showing increased utility for interpreting African genetic studies.

This study conducts a GWAS on urinary albumin-to-creatinine ratio in Sub-Saharan African and non-resident African-ancestry populations, identifying two genome-wide significant loci and highlighting limited transferability of polygenic scores across populations.

Admix-kit provides tools for genetic analysis of admixed populations, enabling simulation, association testing, and polygenic scoring.

H3AGWAS provides a scalable and portable workflow for conducting GWAS, enabling pre-association, association testing, and post-association analysis with containerized software.

The paper analyzes G6PD variant distribution in sub-Saharan Africa and highlights potential risks of using chloroquine/hydroxychloroquine for COVID-19 due to G6PD deficiency.

This study uses molecular dynamics simulations to analyze the impact of rare CYP3A5 variants from Sub-Saharan African populations on protein structure and drug binding.

This study investigates genetic substructure and demographic history of South African Bantu speakers using genome-wide data, revealing fine-scale population structure aligned with geography and linguistics.

This study characterizes ADME gene variation in sub-Saharan African populations, identifying novel variants and highlighting the need for tailored pharmacogenomic approaches.

This study uses short- and long-read metagenomics to analyze gut microbiomes in South African populations, revealing intermediate composition and novel taxa not captured by existing reference databases.

The paper analyzes the interaction between SARS-CoV-2 RBD and ACE2, identifies key residues for binding, and assesses the impact of ACE2 variants on this interaction.

This study analyzes runs of homozygosity in sub-Saharan African populations to uncover demographic history and health-related genetic variation.

The paper compares Runs of Homozygosity (ROH) detected from SNP array and low coverage whole genome sequence data to establish guidelines for combining datasets.