Changes in Cortical Directional Connectivity during Difficult Listening in Younger and Older Adults

Abstract

One way to investigate the mechanisms that underlie speech comprehension under difficult listening conditions is via cortical connectivity. The innovative Network Localized Granger Causality (NLGC) framework was applied to magnetoencephalography (MEG) data, obtained from older and younger subjects performing a speech listening task in noisy conditions, in delta and theta frequency bands. Directional connectivity between frontal, temporal, and parietal lobes was analyzed. Both aging- and condition-related changes were found, particularly in theta. In younger adults, as background noise increased, there was a transition from predominantly temporal-to-frontal (bottom-up) connections, to predominantly frontal-to-temporal (top-down). In contrast, older adults showed bidirectional information flow between frontal and temporal cortices even for speech in quiet, not changing substantially with increased noise. Additionally, younger listeners did not show changes in the nature of their cortical links for different listening conditions, whereas older listeners exhibited a switch from predominantly facilitative links to predominantly sharpening, when noise increased. Graphical Abstract O_FIG O_LINKSMALLFIG WIDTH=169 HEIGHT=200 SRC="FIGDIR/small/541500v1_ufig1.gif" ALT="Figure 1"> View larger version (28K): org.highwire.dtl.DTLVardef@174c132org.highwire.dtl.DTLVardef@37c5a5org.highwire.dtl.DTLVardef@1910e38org.highwire.dtl.DTLVardef@3c94e0_HPS_FORMAT_FIGEXP M_FIG C_FIG HighlightsO_LIDifferent bands show strong differences in directional functional connectivity patterns C_LIO_LIDirectional functional connectivity patterns altered by listening task difficulty C_LIO_LIAging dramatically alters directional functional connectivity patterns in during listening C_LIO_LINature of functional connectivity, additive vs subtractive, depends on age and task C_LI