Yanomami skin microbiome complexity challenges prevailing concepts of healthy skin.

Abstract

The adult skin microbiome contributes to skin homeostasis and generally comprises relatively low microbial complexity, especially sebaceous sites, where lipophilic Cutibacterium and Malassezia spp. predominate. Current understanding of the healthy skin microbiome derives predominantly from studies of western, industrialized populations, with limited representation of diverse cultures and lifestyles. In this study, the skin microbiome of a remote indigenous Yanomami community was investigated, revealing a complex microbial community comprised of 115 novel bacterial genomes. The bacterial community composition included genera common to western skin microbiota and additional diverse taxa, which formed multiplex interactions with a dominant eukaryote, Malassezia globosa. Metatranscriptome-derived functional attributes of the microbial communities contributed to skin homeostasis, fortifying barrier integrity via lipid metabolism and acid production and protecting against oxidative stress. The Yanomami skin microbiome comprised a suite of microbial taxa co-detected within their various surroundings. Longitudinal monitoring of Western expeditioner microbiome revealed acquisition of the Yanomami skin microbiome following immersion into the Amazon and subsequent loss upon return to an industrialized setting. These findings challenge the prevailing Western-centric view of what comprises a healthy adult skin microbiome, suggesting a diverse community that includes bacteria of environmental origin confers benefits not recognized in the current model of healthy skin. Importantly, we highlight the malleability of adult skin microbiome composition, which includes changes sustained by lifestyle modification.