bioRxivNeurosciencePreprint
Altered brain-wide auditory networks in fmr1-mutant larval zebrafish
Lena ConstantiniD, Rebecca Elizabeth PoulseniD, Itia A. Favre‐BulleiD, Michael A. TayloriD, Biao SuniD, Geoffrey J. GoodhilliD, Gilles Claude VanwalleghemiD, Ethan K. ScottiD
Abstract
Altered sensory processing is characteristic of several psychiatric conditions, including autism and fragile X syndrome (FXS). Here, we use whole-brain calcium imaging at cellular resolution to map sensory processing in wild type larval zebrafish and mutants for fmr1, which causes FXS in humans. Using functional analyses and graph theory, we describe increased transmission and reduced filtering of auditory information, resulting in network-wide hypersensitivity analogous to the auditory phenotypes seen in FXS.
- organism: zebrafish
- assay: imaging
- research focus: cell type annotation
- research focus: spatial domain detection
- research focus: differential expression
- research focus: cell-cell communication
- approach: experimental assay
- Citations
- 5
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