Ultrasound-induced Particle Dynamics in Pathological Vascular Vortices

Abstract

Disturbed flow is a hallmark of diseased vasculature, yet its influence on particle behavior under external actuation remains poorly understood. We uncover distinct behaviors of microparticles under disturbed flow when exposed to ultrasound, revealing selective trapping and aggregation phenomena that differ fundamentally between soft and rigid particles. Using microfluidic models of disturbed vascular flow, we show that microbubbles become trapped at the eye of vortices and self-assemble via ultrasound-induced forces. As clusters grow to a critical size, they are ejected and adhere to the wall opposite the ultrasound source, forming nuclei that progressively occupy aneurysm cavities--a mechanism that could enable targeted, noninvasive treatment. These findings reveal an unexplored interplay between ultrasound and hydrodynamic forces, offering a new strategy for ultrasound-guided therapeutic delivery in vascular disease. One-Sentence SummaryVortices are common in diseased arteries, yet we dont know how therapeutic carriers behave in them under ultrasound. We discover that microbubbles self-assemble in vortex cores, then eject and anchor to vessel walls--revealing a new transport regime with therapeutic potential.