Sustained neurotrophic factor cotreatment enhances donor and host retinal ganglion cell survival in mice

Abstract

Retinal ganglion cells (RGCs) lack regenerative capacity in mammals, and their degeneration in glaucoma leads to irreversible blindness. Autologous and allogeneic RGC replacement with stem cell-derived neurons has been established as a promising strategy for vision restoration, but it has been limited by relatively low ( View larger version (24K): org.highwire.dtl.DTLVardef@62d2eorg.highwire.dtl.DTLVardef@1805635org.highwire.dtl.DTLVardef@9bbea7org.highwire.dtl.DTLVardef@101e2f9_HPS_FORMAT_FIGEXP M_FIG C_FIG Engineering the retinal environment with neurotrophic factors to mimic development improves donor and host neuron survival, outgrowth, and function in an optic neuropathy mouse model.