PLoS BiologyGeneticsPeer-reviewed journal article
Leveraging type 1 diabetes human genetic and genomic data in the T1D Knowledge Portal
Parul KudtarkariD, Maria C. CostanzoiD, Ying SuniD, Dongkeun JangiD, Ryan KoestereriD, Josyf C. MychaleckyjiD, Uma NayakiD, Suna Önengüt-GümüşcüiD, Stephen S. RichiD, Jason A. FlannickiD, Kyle J. GaultoniD, Noël P. BurttiD
Abstract
Translating genetic discoveries for type 1 diabetes (T1D) into mechanistic insight can reveal novel biology and therapeutic targets but remains a major challenge. We developed the T1D Knowledge Portal (T1DKP), a disease-specific resource of genetic and functional annotation data that enables users to develop hypotheses for T1D-based research and target discovery. The T1DKP can be used to query genes and genomic regions for genetic associations, identify epigenomic features, access results of bioinformatic analyses, and obtain expert-curated resources. The T1DKP is available at http://t1d.hugeamp.org.
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