Author

Carolyn McGrail

University of California San Diego

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 5 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:statistical model· 6 Assay:GWAS summary statistics· 4 Research Focus:GWAS / association mapping· 3 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Research Focus:fine-mapping· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Kyle J. GaultoniD· 6 shared Joshua ChiouiD· 3 shared Amber M LuckettiD· 2 shared Emily N. GriffiniD· 2 shared Rebecca L. MeltoniD· 2 shared Richard A. OramiD· 2 shared Ruth M. ElgamaliD· 2 shared Aaron J. DeutschiD· 1 shared

Activity by Year

2023-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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6 shared papersGenetic & Genomic Medicine

Kyle J. GaultonORCID

Mutual co-authors in cluster

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6 papers

Recent·Most cited

Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression

Rebecca L. Melton, Sara Jiménez, Weston S. Elison, Luca Tucciarone, Abigail Howell, Gaowei Wang, Denise A. Berti, Elisha Beebe, Michael Miller, Chun Zeng, Carolyn McGrail, Kennedy VanderStel, Katha Korgaonkar, Ruth M. Elgamal, Hannah M Mummey, , Kyle J. Gaulton

This study uses single-cell multiomics and spatial transcriptomics to identify gene regulatory programs in pancreatic cell types that drive type 1 diabetes progression.

Science Advances · Sep 10, 2025Peer-reviewedGenomics

Genetic association of T1D stratified by HLA DR3 and DR4 status reveals heterogeneity in pathways of progression to T1D

Amber M Luckett, Carolyn McGrail, Kathryn Murrall, Emily N. Griffin, Robin N. Beaumont, Gareth Hawkes, William Hagopian, Stephen S. Rich, Michael N. Weedon, Sarah J. Richardson, Richard A. Oram, Kyle J. Gaulton

This study performs a genome-wide association study of T1D stratified by HLA DR3 and DR4 status, revealing genetic and biological heterogeneity in T1D progression.

medRxiv · Aug 13, 2025 · PreprintGenetic & Genomic Medicine

Genetic discovery and risk prediction for type 1 diabetes in individuals without high-risk HLA-DR3/DR4 haplotypes

Carolyn McGrail, Joshua Chiou, Ruth Egamal, Amber M Luckett, Richard A. Oram, Paola Benaglio, Kyle J. Gaulton

This study identifies genetic risk factors for type 1 diabetes in individuals without high-risk HLA-DR3/DR4 haplotypes and develops a new risk score for better classification.

Diabetes Care · Dec 3, 2024Peer-reviewedGenetic & Genomic Medicine

Circulating pancreatic enzyme levels are a causal biomarker of type 1 diabetes

Ruth M. Elgamal, Rebecca L. Melton, Joshua Chiou, Carolyn McGrail, Kyle J. Gaulton

The paper identifies causal biomarkers for type 1 diabetes using protein QTLs and GWAS, revealing roles of pancreatic enzymes and immune processes in disease risk.

medRxiv · Aug 8, 2024 · PreprintGenetic & Genomic Medicine

Genetic association and machine learning improves discovery and prediction of type 1 diabetes

Carolyn McGrail, Timothy J. Sears, Parul Kudtarkar, Hannah K. Carter, Kyle J. Gaulton

This study identifies 165 T1D risk signals and develops a machine learning model, T1GRS, that improves risk prediction for T1D in Europeans and African Americans.

medRxiv · Jul 31, 2024 · PreprintGenetic & Genomic Medicine

Multi-ancestry Polygenic Mechanisms of Type 2 Diabetes Elucidate Disease Processes and Clinical Heterogeneity

Kirk Smith, Aaron J. Deutsch, Carolyn McGrail, Hyunkyung Kim, Sarah C Hsu, Ravi Mandla, Philip H. Schroeder, Kenneth E. Westerman, Łukasz Szczerbiński, Timothy D. Majarian, Varinderpal Kaur, Alice Williamson, Melina Claussnitzer, José C. Florez, Alisa Knodle Manning, , Miriam S. Udler

This study identifies genetic subtypes of type 2 diabetes across diverse ancestries, revealing ancestry-specific risk profiles and BMI thresholds.

medRxiv · Sep 28, 2023 · PreprintGenetic & Genomic Medicine