TMS disruption of the lateral prefrontal cortex increases neural activity in the default mode network when naming facial expressions

Abstract

Recognizing facial expressions is dependent on multiple brain networks specialized for different cognitive functions. In the current study participants (N=20) were scanned using functional magnetic resonance imaging (fMRI) while they performed a covert facial expression naming task. Immediately prior to scanning thetaburst transcranial magnetic stimulation (TMS) was delivered over the right lateral prefrontal cortex (PFC), or the vertex control site. A group whole-brain analysis revealed that TMS induced opposite effects in the neural responses across different brain networks. Stimulation of the right PFC (compared to stimulation of the vertex) decreased neural activity in the left lateral PFC but increased neural activity in three nodes of the default mode network (DMN): the right superior frontal gyrus (SFG), right angular gyrus and the bilateral middle cingulate gyrus. A region of interest (ROI) analysis showed that TMS delivered over the right PFC reduced neural activity across all functionally localised face areas (including in the PFC) compared to TMS delivered over the vertex. These results causally demonstrate that visually recognizing facial expressions is dependent on the dynamic interaction of the face processing network and the DMN. Our study also demonstrates the utility of combined TMS / fMRI studies for revealing the dynamic interactions between different functional brain networks.