Variable and reversible opacification process on IOLs for cataract simulation

Abstract

Understanding vision through mild and dense cataracts is important for vision scientists and IOL developers. There have been virtual simulators using VR headsets for subjective evaluation of cataractous vision. However, a physical intraocular lens with variable cataracts for objective evaluation is not available. In this study, we developed a reversible process that can be selectively applied to the whole or parts of an IOL to affect the opacification level. We used our eye model and developed a cataractous lens simulator for progressive levels of opacification, which is achieved by applying a reversible chemical procedure on the intraocular lens surfaces. After the lens is fully or partially immersed in acetone, subsequent testing of the lens in distilled water results in a progressive change in opacification level within minutes. We measured the quality of vision by obtaining modulation transfer function curves, transmission, and spectroscopic measurements at different opacification levels. By simulating variable opacification across the IOLs, we tested how vision changes from less dense to more dense cataractous regions in a holographic display system with programmable small exit pupils. All results were consistent with the expected vision degradation caused by natural opacification.