GSPlot: Visualizing gene set similarity in enrichment results

Abstract

SummaryInterpretation of gene set enrichment analyses is challenging when the results contain many sets. Similarities in those sets can be used for complexity management. We present GSPlot, a web-based application for visualizing enrichment results of large gene set collections. GSPlot displays gene sets in a two-dimensional space where distances reflect the similarity of their enriched content. This view brings a higher-level structure to the enrichment results and simplifies their interpretation and communication. Availability and implementationGSPlot is available at https://gsplot.cs.umb.edu/. Source code is available at https://github.com/PathwayAndDataAnalysis/gsplot.