bioRxivAnimal Behavior & CognitionPreprint
AI-Discovered Cognitive Models Reveal Novel Insights into Human and Animal Learning
Daniel KasenbergiD, Pablo Samuel CastroiD, Maria Katharina EcksteiniD, Noémi ÉltetőiD, Will DabneyiD, Caroline WangiD, Martin EngelckeiD, Rishika MohantaiD, Aparna DeviD, Matthew BotvinickiD, Nenad TomaševiD, Glenn C TurneriD, Vincent D. CostaiD, Nathaniel D. DawiD, Kimberly StachenfeldiD, Kevin J. MilleriD
Abstract
Scientific models are widely used across the natural sciences as an interface between scientific theories and empirical data [1]. Such models play a key role, for example, in the study of human and animal learning, where they express algorithmic hypotheses and relate them to psychology and neuroscience data [2, 3]. These models are traditionally handcrafted by expert researchers based on existing theory or new insights. Such handcrafted models, however, are now known to fall short of capturing the full richness of behavior, even in their narrow domains [4-7]. An alternative data-driven approach has emerged, seeking to discover new insights by fitting and interpreting flexible models [8-11]. However, these tools require substantial human effort to derive insight from data, and it has been unclear how to discover new ideas from data efficiently. Here, we present DataDIVER, a general approach for automatically discovering computational models from data, and demonstrate that these models surface novel mechanistic insights into human and animal learning. Our approach delivers models that take the form of short computer programs, which are optimized both to fit data well and to be simple. These programs explicitly connect with existing theoretical frameworks and are readily understandable by human scientists. They can also be used to make novel predictions, some of which we show are borne out in re-analysis of existing data. General-purpose tools for surfacing new ideas from data, especially in combination with the large datasets that are increasingly available in many fields, stand to dramatically accelerate scientific discovery.
- organism: human
- organism: mouse
- assay: behavioral assay
- research focus: cell type annotation
- research focus: clustering
- research focus: trajectory inference
- research focus: gene regulatory network inference
- approach: deep learning
- approach: statistical model
- Citations
- 1
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