Vincent D. Costa

Retrograde transduction of dopaminergic cells in substantia nigra of rhesus monkey

This study compares the retrograde transduction efficiency of four viral vectors in dopaminergic neurons of rhesus monkeys after striatal injection.

Spatiotemporal Decoding of Explore-Exploit Decisions in the Human Brain

This study maps the spatiotemporal dynamics of explore-exploit decisions in the human brain using MEG and POMDP modeling during a reinforcement learning task.

AI-Discovered Cognitive Models Reveal Novel Insights into Human and Animal Learning

This paper introduces DataDIVER, an automated method for discovering computational models from data, which reveals novel insights into human and animal learning.

Risk reshapes amygdala representation of choice

The paper shows that risk alters amygdala activity patterns during reward choice, leading to behavioral flexibility.

Synthetic Serum Markers Enable Noninvasive Monitoring of Gene Expression in Primate Brains

This study introduces RMAs, synthetic serum markers that enable noninvasive monitoring of gene expression in primate brains via blood tests over three months.

Erasable Synthetic Serum Markers

This paper introduces erasable serum markers (ESMs) to improve the sensitivity and temporal resolution of brain gene expression monitoring through blood tests.

Contribution of amygdala to dynamic model arbitration under uncertainty

This study investigates the amygdala's role in dynamic model arbitration under uncertainty by comparing behavior in monkeys with and without amygdala lesions.

Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates

The paper analyzes transcriptomic diversity in amygdalar subdivisions across humans and nonhuman primates using single-nucleus RNA sequencing and identifies distinct neuronal subtypes and transcriptional specializations.

Dissociable effects of curiosity and hedonic valence on reinforcement learning

This study investigates how curiosity and hedonic valence influence reinforcement learning in rhesus macaques, finding that novelty seeking is driven by optimistic priors rather than valence-dependent curiosity.

Transcriptomic landscape of mammalian ventral pallidum at single-cell resolution

The paper defines the transcriptional taxonomy of ventral pallidum cell types across mice, macaques, and baboons using snRNA-seq and in situ hybridization, finding transcriptional conservation and unique subclusters in primates.

Recurrent activity within microcircuits of macaque dorsolateral prefrontal cortex tracks cognitive flexibility

The paper examines microcircuit activity in macaque dlPFC using calcium imaging, showing that spontaneous activity is maintained by microcircuit architecture and correlates with cognitive performance.

A pragmatic reevaluation of the efficacy of nonhuman primate optogenetics for psychiatry

The paper reevaluates the efficacy of nonhuman primate optogenetics for psychiatry, finding lower success rates when applying more relevant criteria to human neuropsychiatric disease.

Novel entropy-based metrics for predicting choice behavior based on local response to reward

The paper introduces entropy-based metrics to predict choice behavior in mice and monkeys, explaining 50% and 41% of matching variance, and develops a more accurate model based on these metrics.

Adolescent dopamine neurons represent reward differently during action and state guided learning

This study shows that adolescent dopamine neurons in rats respond differently to reward in Pavlovian and operant conditioning, suggesting distinct motivational processes.

The neurocomputational architecture of explore-exploit decision making

This study identifies a conserved cortico-subcortical architecture for explore-exploit decision making in humans and monkeys using computational models of fMRI data.