Human Cognitive Ability and the P300 Event-Related Brain Potential

Abstract

Human intelligence is essential to understand complex ideas, to engage in various forms of reasoning, to learn from experience, and to adapt to new situations by taking thought. The P300 event-related brain potential has been related to intelligence scores and thus represents as a promising biomarker of general cognitive ability. However, empirical results are characterized by enormous heterogeneity, and a quantitative assessment of this literature is lacking. This preregistered meta-analysis provides the first systematic overview of neuroscientific studies that have examined associations between general cognitive ability and the P300 in healthy adult participants. Out of 5641 articles screened, 49 studies with up to 381 effects were eligible for PRISMA-based meta-analytic comparison. Study quality was evaluated using a novel Study Design and Implementation Assessment Device, which we developed particularly for Individual Difference Research (DIAD-ID) and provide together with our analysis code as free online resources to support future meta-analyses. Confirming our hypotheses, a small but significant positive across-study association was observed for general cognitive ability and P300 amplitudes (r = .13; 95%-CI [.06, .19]), while a significant negative across-study association was revealed for P300 latencies (r = -.18; 95%-CI [-.24, -.13]). Study heterogeneity was substantial, and sub-analyses highlighted potential moderators such as type of the task during EEG recording. We discuss limitations, open questions, and provide concrete guidelines for future research on the neurobiological underpinnings of individual differences in cognitive ability.