Changes in urinary proteome in healthy individuals taking multi-vitamin/mineral supplements

Abstract

Multivitamin/mineral supplements are widely used in many populations. Urine proteome has not been used to investigate its overall effects on healthy individuals. In this study, the urine proteome changed after taking compound nutrient supplements for 2 weeks and 4 weeks, and the differential proteins and their enriched pathways may be associated with nutrient supplementation. We noted that after taking the supplements for 2 weeks, the amount of erythropoietin receptor in urine was average 449 times higher than before, with four out of nine people experiencing changes from 0 to 14635, 11851, 11181, and 5930. The results of this study revealed that the urine proteome can provide new clues about the relatively short-term health effects of the supplements. It may help optimize guidelines and recommendations for the use of supplements.