Mapping the task-general and task-specific neural correlates of speech production: meta-analysis and fMRI direct comparisons of category fluency and picture naming

Abstract

Improving our understanding of the neural network engaged by different forms of speech production is a crucial step for both cognitive and clinical neuroscience. We achieved this aim by exploring two of the most commonly utilised speech production paradigms in research and the clinic, which have been rarely, if ever, compared directly: picture naming and category fluency. This goal was achieved in this two study investigation through a full ALE meta-analysis as well as a targeted fMRI study. Harnessing the similarities and differences between the two tasks offers a powerful methodology to delineate the core systems recruited for speech production, as well as revealing task-specific processes. The results showed that both tasks engaged a bilateral fronto-temporal speech production network, including executive and motor frontal areas, as well as semantic representational regions in the ATL, bilaterally. In addition, it was found that the extent of relative frontal lateralisation was task-dependent with the more executively-demanding category fluency task showing augmented left hemisphere activation. The results have implications for neurocomputational speech production models and the clinical assessment of speech production impairments. Open access: For the purpose of open access, the UKRI-funded authors have applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising from this submission.