Thermodynamic Modeling of mRNA with the Addition of Precipitants
Vico Tenberg, Pierre J. Walker, Pavan Inguva, Maria del Carme Pons Royo, A. Acevedo, Vernon S Lin, Marion Pang, Zhen‐Gang Wang, Allan S. Myerson, Richard D. Braatz
This study uses thermodynamic modeling to predict mRNA solubility and identifies hydrogen bonding disruption as a key factor in precipitation.
bioRxiv · Oct 18, 2025 · PreprintBiophysics