C1Q-associated adaptive myeloid remodelling accompanies early response to BCMA CAR-T therapy in multiple myeloma
Shubing Wang, Qian Wang, Yan-Ruide Li, Song Li
In a ten-patient multiple myeloma reanalysis, myeloid pseudobulk from day-30 BCMA CAR-T responders showed C1Q enrichment with interferon-γ signalling, not cholesterol efflux; patient-level composite scores stayed exploratory.
bioRxiv · Aug 25, 2026 · PreprintImmunology✦ In-depth digest