Topic · Cardiology and Cardiovascular Medicine · Medicine

Antiplatelet Therapy and Cardiovascular Diseases

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

5 papers

A Prospective Observational Study to Assess the Impact of Pharmacogenetics on Outcomes in Vascular Surgery (PROSPER)

Kerry Anne Burke, Selman Mirza, Stuart James Wright, Nicholas S. Greaves, William G. Newman, John Henry McDermott

This study investigates how CYP2C19 genetic variants affect outcomes in CLTI patients taking clopidogrel post-revascularisation.

medRxiv · May 24, 2024 · PreprintGenetic & Genomic Medicine

Implementing a Pharmacogenomic-driven Algorithm to Guide Antiplatelet Therapy among Caribbean Hispanics: A Nonrandomized Prospective Cohort Study.

Héctor Nuñez-Medina, Mariangeli Moneró-Paredes, Lorna M Torres, Enrique Leal, Lorena González‐Sepúlveda, Ángel M. Mayor, Jessicca Y. Renta, Edgardo R González-García, Ariel Gonzaléz, Kyle Melín, Stuart Alexander Scott, Gualberto Ruaño, Dagmar F. Hernández-Suárez, Jorge Duconge-Soler

This study evaluates a pharmacogenomic-driven algorithm to guide antiplatelet therapy in Caribbean Hispanic patients post-PCI, showing reduced MACCE incidence with genotype-guided treatment.

medRxiv · Dec 5, 2023 · PreprintGenetic & Genomic Medicine

CYP2C19 Polymorphisms and Clinical Outcomes Following Percutaneous Coronary Intervention (PCI) in the Million Veterans Program

Catherine Coffinier, Kevin A. Friede, Mary E. Plomondon, Kyung Min Lee, Zhenyu Lu, Julie Ann Lynch, Scott L. DuVall, Jason L. Vassy, Stephen W. Waldo, John H. Cleator, Thomas M. Maddox, Daniel James Rader, Themistocles L. Assimes, Scott M. Damrauer, Philip S. Tsao, , VA Million Veteran Program

This study examines the association between CYP2C19 polymorphisms and major adverse cardiac events after PCI in patients with ACS or SIHD, finding no significant overall association but a numerical increase in risk for ACS patients.

medRxiv · Oct 25, 2023 · PreprintGenetic & Genomic Medicine

EXPRESSION OF VARIABILITY OF THE CYP2C19*2 GENE IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION FROM A SOUTH AMERICAN HOSPITAL AND ITS FUTURE RELEVANCE IN THE INTERACTION BETWEEN GENETICS AND CARDIOLOGY.

Luis Dulcey, Juan Sebastián Theran León, Jaime Gomez, Rafael Guillermo Parales Strauch, Raimondo Caltagirone, Edgar Blanco, María Paula Ciliberti Artavia, Juan Camilo Martínez, Valentina Cabrera Peña, Maria Amaya

The paper examines the frequency of the CYP2C19*2 polymorphism in South American ACS patients and its implications for clopidogrel response.

medRxiv · Aug 18, 2023 · PreprintGenetic & Genomic Medicine

CYP2C192, CYP2C1917 and ITGB3 (PlA1/A2) polymorphisms and resulting therapeutic alterations of clopidogrel and aspirin: A clinical screening among CVD patients who undergone PCI

Tasnova Tasnim Nova, Ishrat Jahan, NAM Momenuzzaman, Sikder Nahidul Islam Rabbi, Thomas M. C. Binder, Mohammad Safiqul Islam, Md. Rabiul Islam, Abul Hasnat, Zabun Nahar

The paper investigates genetic polymorphisms in CYP2C19 and ITGB3 genes and their impact on clopidogrel and aspirin efficacy in cardiovascular patients post-PCI.