Topic · Pathology and Forensic Medicine · Medicine

Genetic factors in colorectal cancer

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

Genetic & Genomic Medicine·medRxivPreprint·Oct 21, 2026
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LynchRisk: a Bayesian network to estimate the probability of Lynch syndrome based on pedigree and tumor characteristics
Alexandra Lefebvre, Patrick R. Benusiglio, Grégory Nuel
LynchRisk estimates Lynch syndrome probability using pedigree, cancer history, and tumor MMR status through a Bayesian model.
DOI 10.64898/2026.10.14.26365520
Bayesian inference
·𝕏 Post·Bluesky
Cancer Biology·bioRxivPreprint·Oct 20, 2026
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Inflammation is an essential trigger for POLE-driven ultramutated colorectal cancer
Md. Kawsar Mustofa, Mitzi Aguilar, He Zhang…+7 more authors·Hasan Zaki
This study shows that inflammation triggers POLE-mutant colorectal cancer in mice, revealing inflammation as a key driver and establishing a preclinical model for drug discovery.
DOI 10.64898/2026.10.19.760274
mouse·whole-genome sequencing
·𝕏 Post·Bluesky