Topic · Plant Science · Agricultural and Biological Sciences

Natural Compound Pharmacology Studies

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

2 papers

Elucidating the Impact of Hypericum alpestre Extract and L-NAME on the PI3K/Akt Signaling Pathway in A549 Lung Adenocarcinoma Cells

Hayarpi Javrushyan, Mikayel M․ Ginovyan, Gayane Petrosyan, Mery Qocharyan, Zaruhi I. Karabekian, Smbat Gevorgyan, Zaruhi Karabekian, Alina Maloyan, Nikolay V. Avtandilyan

This study investigates how Hypericum alpestre extract and L-NAME affect the PI3K/Akt signaling pathway in A549 cells, showing enhanced apoptosis and inhibition of TNFα/COX-2 and VEGFα/MMP-2 pathways.

PLoS ONE · Apr 3, 2025Peer-reviewedCancer Biology

Garcinone C suppressed the proliferation of gastric cancer cells through regulating Hedgehog signaling

Yimeng Zhou, Jin Tae Kim, Jung Won Kwon, Ga-Yeon Lee, Hui Mang Son, Kang Hyuk Lee, Shuai Qiu, Hong Jin Lee

This study shows garcinone C inhibits gastric cancer cell proliferation by suppressing Hedgehog signaling through Gli1/2 downregulation and nuclear translocation blockage.

Journal of Food Biochemistry · Jan 1, 2025Peer-reviewedCancer Biology