Bone and Joint Diseases

Multidimensional Mechanistic Study of Panax Notoginseng Saponins in the Treatment of Alcohol-Induced Osteonecrosis of the Femoral Head: Integrating Network Pharmacology, Molecular Dynamics Simulation and In Vivo Validation

This study identifies PNS active components, targets, and pathways for AIONFH using network pharmacology, molecular dynamics, and animal experiments, showing PNS inhibits osteocyte apoptosis through multi-component, multi-target mechanisms.

ATG5 regulates autophagy-apoptosis-ER stress dysregulation in steroid-induced osteonecrosis of the femoral head (SONFH) pathogenesis

This study investigates how ATG5 regulates autophagy, apoptosis, and ER stress in SONFH and shows that ATG5 silencing reduces pathology by blocking these pathways.