Erythrocyte aging links hypocalcemia to impaired flow dynamics and oxygen transport through volume dysregulation
Jiaqi Lim, Justin Kok Soon Tan, Yijia Yuan, Elaine Shi An Chen, Yujin Song, Sim Leng Tien, Hwa Liang Leo, Sangho KIM
This study shows that aging red blood cells rely on calcium for volume stability under shear stress, and impaired calcium regulation leads to flow and oxygen transport issues.
bioRxiv · Oct 28, 2026 · PreprintBioengineering