Obstructed tear duct causes epiphora and precocious eyelid opening due to disruption of Prickle 1-mediated Wnt/PCP signaling
Dianlei Guo, Jiali Ru, Jiaying Fan, Rong Ju, Kangxin Jin, Hong Wei Ouyang, Lai Wei, Yizhi Liu, Chunqiao Liu
This study identifies Prickle 1's role in tear duct development, showing its necessity for proper outgrowth and its link to epiphora and precocious eyelid opening in mice.
bioRxiv · Apr 17, 2020 · PreprintGenetics