Pharmaceutical studies and practices

Stochastic Differential Equations (SDEs) in NONMEM for Probing Population Pharmacokinetic Model Misspecification: Diagnostic Utility, Practical Considerations, and Future Directions

This work evaluates stochastic differential equations (SDEs) in NONMEM as a diagnostic tool for detecting population pharmacokinetic model misspecification through simulation and estimation scenarios.

Model-informed Deep Q-Networks to Guide Infliximab Dosing in Pediatric Crohn's Disease

This study develops a model-informed Deep Q-Network to automate infliximab dosing in pediatric Crohn's disease, achieving high target attainment with minimal overtreatment.

Enhancing Pharmacometric Modeling with Full Bayesian Inference and Students t-Based M3 Censoring: A Simulated Population PK Study on Robust Handling of Outliers and Censored Data

This study evaluates Bayesian modeling strategies for population pharmacokinetics, finding that Students t-based M3 censoring improves accuracy and precision in handling outliers and censored data.