Current clinical use of polygenic scores will risk exacerbating health disparities
Alicia R. Martin, Masahiro Kanai, Yoichiro Kamatani, Yukinori Okada, Benjamin M. Neale, Mark J. Daly
Eurocentric GWAS make polygenic scores less accurate in non-Europeans (mean 4.9-fold lower for UK Biobank Africans); equal-sized ancestry-matched GWAS predict better in Japanese and British individuals.
Nature Genetics · Mar 29, 2019Peer-reviewedGenetics✦ In-depth digest