Nobiletin, a Polymethoxyflavonoid, Activates the Desuccinylase Activity of SIRT5 and Prevents the Development of Heart Failure
Yoichi Sunagawa, Masafumi Funamoto, Toshihide Hamabe‐Horiike, Kehima Hieda, Seiichiro Yabuki, Midori Tomino, Yoshimi Ikai, Anna Suzuki, Ogawahara Shintaro, Asami Yabuta, Hana Sasaki, Ayaka Ebe, Shiomi Naito, Hidemichi Takai, Kana Shimizu, , Tatsuya Morimoto
This study shows nobiletin prevents heart failure by enhancing SIRT5 desuccinylase activity, which inhibits p300-HAT activity in mice.
bioRxiv · Jan 16, 2024 · PreprintMolecular Biology