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This study shows that tardigrades can survive and revive after spaceflight, with transcriptomic changes indicating stress responses and reduced energy metabolism.

This study shows subaerial green algae from Chlorophyta and Streptophyta assemble distinct phycosphere communities from soil, with host identity driving bacterial composition more strongly than fungal.

This study uses Mendelian randomization to assess if topiramate affects anorexia nervosa and binge eating risk, finding a potential link with binge eating but not anorexia.

This study models the affinity maturation process to assess the roles of proliferation and mutation in the humoral immune response, finding that multiple strategies can yield optimal outcomes.

StableProt predicts protein thermostability and organismal optimal growth temperature using a structure-aware deep learning framework, achieving high accuracy and robustness across temperature regimes.

This study maps human lung fibrosis in 3D, showing how structural changes in tissue microarchitecture drive maladaptive repair states and disease progression.

The paper introduces SPACE-Tag, a spatial CUT&Tag method for chromatin profiling, and applies it to the mouse brain to reveal age-related chromatin and transcriptome changes.

The paper synthesizes and tests microbially conjugated bile acids (MCBAs) to determine their effects on Clostridioides difficile lifecycle stages, revealing amino acid-dependent inhibitory or promoting effects.

This study identifies the methionine cycle as a driver of mesenchymal traits in PDA, showing that targeting SAHH reduces metastasis and improves survival.

This study uses simulations to show that low-dimensional optogenetic stimulation can effectively control neural latent dynamics with fewer channels than neurons, guiding future hardware design.

This study identifies novel diagnostic antigens for coccidioidomycosis using high-dimensional peptide serology, showing improved accuracy in distinguishing infected individuals from controls.

This study shows that Citrobacter rodentium infection disrupts the colonic mucus barrier by ablating intercrypt goblet cells, leading to impaired barrier integrity and enhanced pathogen colonization.

This study shows that dual inhibition of MLK3 and LRRK2 with URMC-099 reduces PD pathology and motor deficits in an AAV-haSyn rat model.

This study identifies three distinct pathways maintaining kinetochore integrity during meiosis in budding yeast, with distinct temporal requirements and interactions involving Ctf19cCCAN, Mif2CENP-C, and Cse4CENP-A-Okp1CENP-Q-Ame1CENP-U.

This study identifies kinome biomarkers and shows therapeutic rescue in cGMP-linked retinal degeneration using LP-CN03 in mouse models.

The paper introduces a SURFAR platform to identify and characterize new P. aeruginosa phages by targeting specific receptors, isolating two novel phages with distinct host ranges.

This study uses nonequilibrium molecular dynamics to show frequency-dependent structural changes in amyloid fibrils under terahertz pulses, identifying two electric-field thresholds for disruption.

This study identifies FASN's RNA binding sites and shows its depletion reduces translational efficiency of associated mRNAs.

The paper reports the cryo-EM structures of an Acinetobacter baumannii podovirus, revealing its capsid maturation mechanism and providing a reference for phage engineering.

This study shows that gene clusters for magnetite formation in bacteria confer resistance to hydrogen peroxide, supporting an early origin of magnetotactic bacteria before Earth's oxygenation.