Liang‐Dar Hwang

Investigating the potential effect of topiramate on anorexia nervosa and binge eating behaviour using drug-target Mendelian randomization

This study uses Mendelian randomization to assess if topiramate affects anorexia nervosa and binge eating risk, finding a potential link with binge eating but not anorexia.

Genome-wide association study of food liking and food preference patterns in young adults

This study conducts a GWAS of food liking in young adults, identifying 16 genome-wide significant associations across 14 traits and one food preference pattern.

Direct and INdirect effects analysis of Genetic lOci (DINGO): A software package to increase the power of locus discovery in GWAS meta-analyses of perinatal phenotypes and traits influenced by indirect genetic effects

DINGO improves locus discovery in GWAS of perinatal traits by combining maternal and fetal GWAS data through meta-analysis and novel statistical tests, identifying more genetic loci than separate analyses.

Using adopted individuals to partition maternal genetic effects into prenatal and postnatal effects on offspring phenotypes

This paper uses structural equation modeling to partition maternal genetic effects into prenatal and postnatal components using adoption data from the UK Biobank.

Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data: a comparison of multivariate methods

The paper compares multivariate methods to estimate direct and indirect genetic effects on offspring phenotypes using GWAS summary data, finding Genomic SEM most accurate and identifying novel fertility loci.

Modeling Parent-Specific Genetic Nurture in Families with Missing Parental Genotypes: Application to Birthweight and BMI

The paper extends a method to estimate parent-specific genetic effects on offspring traits, applying it to UK Biobank data to analyze birthweight and BMI.

Estimating indirect parental genetic effects on offspring phenotypes using virtual parental genotypes derived from sibling and half sibling pairs

This paper estimates indirect parental genetic effects on offspring phenotypes using virtual parental genotypes derived from sibling and half-sibling pairs, demonstrating the feasibility of this approach with GWAS data.

Inference and visualization of phenome-wide causal relationships using genetic data: an application to dental caries and periodontitis.

The paper develops an automated pipeline using the latent causal variable approach to infer phenome-wide causal relationships, applying it to dental caries and periodontitis to show they are downstream consequences of other traits.

Genome-wide association study identifies 48 common genetic variants associated with handedness.

This study identifies 48 genetic variants associated with handedness using a large GWAS, highlighting polygenic nature and genetic links to neuropsychiatric traits.

Complex-Traits Genetics Virtual Lab: A community-driven web platform for post-GWAS analyses

A web platform bundling LD-score regression, DEPICT, MetaXcan, SMR, GSMR and fastBAT over uploaded or 1,500-plus public GWAS summary statistics, with precomputed gene, pathway and tissue results.

Bivariate genome-wide association analysis strengthens the role of bitter receptor clusters on chromosomes 7 and 12 in human bitter taste

This study performs a bivariate GWAS to identify new common variants influencing bitter taste perception, finding small-effect SNPs on chromosomes 7 and 12.