Validated machine learning algorithm with sub-clonal sensitivity reveals widespread pan-cancer human leukocyte antigen loss of heterozygosity
Rachel Marty Pyke, Dattatreya Mellacheruvu, Steven Dea, Charles W. Abbott, Simo V. Zhang, Lee McDaniel, Éric Levy, Gabor T. Bartha, John S. West, Michael P. Snyder, Richard Chen, Sean Michael Boyle
The paper develops DASH, a machine learning algorithm to detect HLA LOH in cancer, showing 18% prevalence across 611 patients and correlations with PD-L1 and MSI.
bioRxiv · May 20, 2021 · PreprintBioinformatics