Psychiatric polygenic profiles characterize difficult-to-treat depression versus antidepressant responders in the AGDS:Cell-o cohort
Brittany L. Mitchell, Deborah Gilroy, Leanne M. Wallace, Jacqueline Kiewa, Richard Parker, Lorelle Nunn, Alicia Walker, Tian Lin, Laura Ziser, G English, Michael F. O'Neil, RAN Pertile, Sarah McKenna, Samuel James Hockey, A Hill, , Naomi R. Wray
The paper identifies polygenic score differences between antidepressant responders and difficult-to-treat depression groups in the AGDS:Cell-o cohort, suggesting biological distinctions and potential for early stratification.
medRxiv · Sep 16, 2025 · PreprintGenetic & Genomic Medicine