Andrew Mark McIntosh

Rare coding variation implicates thirteen genes in bipolar disorder across 232,536 individuals from global populations

A rare-variant analysis of FADS-related metabolites in Major Depression

This study analyzes rare variants in the FADS region and their associations with metabolites and Major Depression using genome-wide sequencing data from large cohorts.

Analysis of Rare Coding Variation Identifies New Genetic Contributors to Schizophrenia

Ultra-rare damaging coding variants in 87,959 schizophrenia cases and 150,587 controls implicate 40 genes (16 exome-wide, 24 at 5% FDR), half overlapping autism, developmental delay or bipolar genes.

Genome-wide analysis of 439 mass spectrometry-based proteomic profiles in a population of 15,035 Scottish individuals

The paper performs genome-wide association studies on 439 high-abundance serum proteins in 15,035 Scottish individuals, identifying 1,553 SNP signals and 13 putative causal protein-outcome associations.

General cognitive function and the brain's structural connectome

The paper shows that general cognitive function is supported by a widespread white matter network across multiple brain regions and connectivity measures.

Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorder

This study identifies genetic differences between fear-based anxiety disorders and generalised anxiety disorder using GWAS, finding partial genetic distinction and shared liability to internalising psychopathology.

Cohort Profile: Investigating Antidepressant Response within Generation Scotland

The paper describes the AMBER program's cohort profile, collecting questionnaire data on antidepressant response from Generation Scotland participants to develop phenotypes and link with biological data.

Childhood Maltreatment and Deviations from Normative Brain Structure: Results from 3,711 Individuals from the ENIGMA MDD and ENIGMA PTSD

The paper examines how childhood maltreatment affects brain structure in 3,711 individuals with MDD and PTSD, finding age- and sex-specific brain morphometric differences.

Co-expression-based models improve eQTL predictions and highlightnovel transcriptome-wide genes associated with schizophrenia

The paper introduces co-expression-based models to improve eQTL predictions and identifies novel schizophrenia-associated genes using brain RNA-seq data.

Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling

This paper identifies 58 genome-wide significant loci for major anxiety disorders using a large meta-analysis and highlights GABAergic signaling as a potential mechanism.

Methodological Considerations When Using Polygenic Scores to Explore Parent-Offspring Genetic Nurturing Effects

This study examines genetic nurturing effects using polygenic scores in parent-offspring trios and identifies biases when parental phenotypes are included.

Estimating Disorder Probability Based on Polygenic Prediction Using the BPC Approach

The paper introduces the BPC approach to improve polygenic score calibration for binary disorders, achieving better calibration than existing methods in simulated and empirical data.

Genome-wide association study of adolescent-onset depression

This study identifies 52 genetic variants associated with adolescent-onset depression through a large GWAS, revealing age-specific mechanisms and potential drug targets.

Psychiatric polygenic profiles characterize difficult-to-treat depression versus antidepressant responders in the AGDS:Cell-o cohort

The paper identifies polygenic score differences between antidepressant responders and difficult-to-treat depression groups in the AGDS:Cell-o cohort, suggesting biological distinctions and potential for early stratification.

Lifetime brain atrophy estimated from a single MRI: measurement characteristics and genome-wide correlates

This paper evaluates methods to estimate lifetime brain atrophy from a single MRI scan and identifies genetic correlates, finding that the residual method best captures brain shrinkage and has strong heritability.

Genome-wide analyses of quantitative generalised anxiety symptom severity

This study conducts a genome-wide association analysis of generalised anxiety symptom severity, identifying 80 significant variants and showing genetic correlations with other mental and physical health traits.

Genome-wide meta-analysis of panic attacks and disorder identifies genetic risk factors and implicates multiple body systems in panic and other psychiatric disorders

This study identifies genetic risk factors for panic attacks and disorder through genome-wide meta-analysis and links them to multiple body systems and neuronal functions.

Data Resource Profile: Whole Blood DNA Methylation Resource in Generation Scotland (MeGS)

The paper describes a large DNA methylation dataset from the Generation Scotland cohort, providing methylation profiles and associated phenotypes for research purposes.

Dissecting heterogeneity in cortical thickness abnormalities in major depressive disorder: a large-scale ENIGMA MDD normative modelling study

This study uses normative modeling to analyze cortical thickness deviations in MDD patients and healthy controls, finding large overlaps and significant heterogeneity in extreme deviations across individuals.

A novel framework to build saliva-based DNA methylation biomarkers: quantifying systemic chronic inflammation as a case study

This paper introduces a framework to build saliva-based DNA methylation biomarkers, demonstrating a new epigenetic clock (InflammAge) that quantifies systemic chronic inflammation and outperforms CRP in several health outcomes.

DNAm scores for serum GDF15 and NT-proBNP levels associate with a range of traits affecting the body and brain

The paper develops epigenetic scores for GDF15 and NT-proBNP levels, showing associations with disease risks and brain health traits in two cohorts.

Meta-analysis of CYP2C19 and CYP2D6 metabolic activity on antidepressant response from 13 clinical studies using genotype imputation

This study examines the association between CYP2C19 and CYP2D6 metabolic phenotypes and antidepressant response using genotype imputation across 13 studies, finding no significant associations after correction for multiple testing.

Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants.

The paper evaluates the accuracy of polygenic risk scores for MDD in African ancestry UK Biobank participants using European and African GWAS data, finding lower predictive power from European-derived PRS.

Genome-wide study of half a million individuals with major depression identifies 697 independent associations, infers causal neuronal subtypes and biological targets for novel pharmacotherapies.

This study identifies 697 genetic associations for major depression using GWAS, infers causal neuronal subtypes, and suggests potential drug targets and repurposing opportunities.

General and specific patterns of cortical gene expression as substrates of complex cognitive functioning

The paper identifies general and specific patterns of cortical gene expression related to cognitive functioning using principal component analysis and validates them across datasets.

Blood-based DNA methylation study of alcohol consumption

This paper develops an epigenetic score to objectively measure alcohol consumption using blood-based DNA methylation and validates it across multiple cohorts, finding associations with brain health metrics.

Feature pre-selection for the development of epigenetic biomarkers

This paper introduces RTFS, a method for pre-selecting CpGs for disease prediction models, and shows it performs well for predicting type 2 diabetes onset risk.

Methylome-wide association studies of traumatic injury identifies differential DNA methylation of synaptic plasticity and GABAergic-signalling.

The paper identifies differential DNA methylation patterns associated with traumatic injury in individuals with MDD compared to controls, highlighting synaptic plasticity and GABAergic-signalling pathways.

Genetic structure of major depression symptoms across clinical and community cohorts

This study identifies genetic subtypes of major depressive symptoms by analyzing data from clinical and community cohorts, finding distinct factors for appetite/weight symptoms and missing data patterns.

Development and validation of DNA Methylation scores in two European cohorts augment 10-year risk prediction of type 2 diabetes