A>G substitutions on a heavy chain of mitochondrial genome marks an increased level of aerobic metabolism in warm versus cold vertebrates .
A. G. Mikhailova, D. Iliushchenko, V. Shamanskiy, A. A. Mihailova, K. Ushakova, E. Tretiakov, S. Oreshkov, D. Knorre, L. Polishchuk, D. Lawless, A. Kuzmin, S. Denisov, I. Kozenkov, I. Mazunin, W. Kunz, , K. Popadin
The paper examines A>G substitutions in mtDNA across vertebrates, finding higher rates in warm-blooded species, suggesting temperature influences oxidative damage and mutational patterns.
bioRxiv · Jul 25, 2020 · PreprintEvolutionary Biology