Cell BiologybioRxivPreprint
Molecular and phenotypic blueprint of the hematopoietic compartment reveals proliferation stress as a driver of age-associated human stem cell dysfunctions
E. Lettera, S. Scala, L. Basso-Ricci…·R. Di Micco
The paper analyzes HSPC aging across the lifespan, finding age-related epigenetic dysregulation and impaired response to proliferative stress, using xenotransplantation models.
DOI 10.1101/2023.09.15.557553