Stiffness Sensing by Smooth Muscle Cells:Continuum Mechanics Modeling of the Acto-Myosin Role
A.-A. Karkhaneh Yousefi, C. Petit, A. Ben Hassine, S. Avril
This study develops a continuum mechanics model to simulate how aortic smooth muscle cells sense and respond to substrate stiffness through acto-myosin contractility, showing good agreement with traction force measurements and nuclear deformation predictions.
bioRxiv · May 2, 2023Biophysics