Analysis of gene expression and mutation data points on contribution of transcription to the mutagenesis by APOBEC enzymes
A. Chervova, B. Fatykhov, A. Koblov, E. Shvarov, J. Preobrazhenskaya, D. Vinogradov, G. V. Ponomarev, M. S. Gelfand, M. D. Kazanov
This study analyzes gene expression and whole genome sequencing data to assess the role of transcription in APOBEC-induced mutagenesis compared to replication, finding similar impacts from both processes in transcribed regions.
bioRxiv · Apr 14, 2021Cancer Biology