Author

A. E. Leffler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

D. E. Shaw· 1 shared E. T. Kim· 1 shared S. Sagawa· 1 shared V. P. Mysore· 1 shared Y. Shan· 1 shared

Activity by Year

2021-2021 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperBiophysics

D. E. Shaw

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1 paper

Recent·Most cited

How does a small molecule bind at a cryptic binding site?

Y. Shan, V. P. Mysore, A. E. Leffler, E. T. Kim, S. Sagawa, D. E. Shaw

This study uses molecular dynamics simulations and free energy perturbation to identify and characterize small molecule binding at cryptic sites in protein-protein interactions.

bioRxiv · Mar 31, 2021Biophysics