Author

A. E. Sousa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. R. M. Almeida· 2 shared A. A. S. F. Raposo· 1 shared A. Godinho-Santos· 1 shared A. Iksi· 1 shared A. Serra-Caetano· 1 shared D. Kuzilkova· 1 shared D. Novak· 1 shared G. A. Saad· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

A. R. M. Almeida

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Author profile →

2 papers

Recent·Most cited

Decoding mutational hotspots in human disease through the gene modules governing thymic regulatory T cells

A. A. S. F. Raposo, P. Rosmaninho, S. L. Silva, S. Paco, M. E. Brazao, A. Godinho-Santos, Y. Tokunaga-Mizoro, H. Nunes-Cabaco, A. Serra-Caetano, A. R. M. Almeida, A. E. Sousa

The paper identifies gene regulatory modules in thymic regulatory T cells to prioritize variants in complex diseases and uncover mutational hotspots.

bioRxiv · Dec 27, 2023Immunology

Deconstructing Complexity: A Computational Topology Approach to Trajectory Inference in the Human Thymus with tviblindi

J. Stuchly, D. Novak, N. Brdickova, P. Hadlova, V. Sadilek, A. Iksi, D. Kuzilkova, M. Svaton, G. A. Saad, P. Engel, H. Luche, A. E. Sousa, A. R. M. Almeida, T. Kalina

This paper introduces tviblindi, a trajectory inference tool for thymus development, revealing new insights into T cell maturation and regulatory T cell subpopulations.

bioRxiv · Jul 13, 2023 · PreprintImmunology