Role of lipid nanodomains for inhibitory FcγRIIb function
F. Spiegel, M. F. W. Trollmann, S. Kara, M. Pöhnl, A. F. Brandner, F. A. Nimmerjahn, A. Lux, R. A. Böckmann
This study investigates the lipid environment and conformational dynamics of FcγRIIb and its I232T variant using simulations and assays, finding that they interact with specific lipids rather than lipid rafts and that multivalent IgG complexes may stabilize receptor function.
bioRxiv · May 9, 2023 · PreprintImmunology