Modifications in the piperazine ring of nucleozin affects anti-influenza activity
E. Correa-Padilla, A. Hernandez-Cano, G. Cuevas, Y. Acevedo-Betancur, F. Esquivel-Guadarrama, A. Madariaga-Mazon, K. Martinez-Mayorga
The paper evaluates nucleozin analogs with modified piperazine rings, finding that increased conformational flexibility reduces anti-influenza activity and supports a QSAR model for predicting activity.
bioRxiv · Oct 20, 2022Pharmacology & Toxicology