A large disordered region confers a wide spanning volume to vertebrate Suppressor of Fused as shown in a trans-species solution study.
S. Makamte, A. Jabrani, A. Paquelin, A. Plessis, M. Sanial, A. Thureau, O. Roudenko, F. Oteri, M. Baaden, V. Biou
The paper compares the solution structures of SuFu from drosophila, zebrafish, and human, showing that vertebrate SuFu's IDR2 spans a large volume, enabling functional interactions and post-translational modifications.
bioRxiv · Jun 14, 2021Biophysics