Expression-based analyses indicate a central role for hypoxia in driving tumor plasticity through microenvironment remodeling and chromosomal instability
A. Jing, F. S. Vizeacoumar, S. Parameswaran, B. Haave, C. E. Cunningham, Y. Wu, R. Arnold, K. Bonham, A. Freywald, J. Han, F. J. Vizeacoumar
The paper identifies early hypoxia-driven transcriptomic changes in TNBC that promote chromosomal instability and microenvironment remodeling, enabling tumor evolution.
bioRxiv · May 29, 2018Cancer Biology