cancer & tumor microenvironment

This study identifies 28S rsRNA-CTC_L20 as a regulator of PASMC proliferation in pulmonary hypertension by modulating BHB production and PKM2 β-hydroxybutyrylation.

This study shows that PRDX6's iPLA2 activity protects hepatocarcinoma cells from ferroptosis by maintaining lipid homeostasis and mitophagy.

This study identifies KLRG1+ cytotoxic CD4+ T cells in tumors that retain immunosuppressive function, derived from Tregs, and suggests KLRG1-targeted depletion may be more effective than blockade in cancer therapy.

This study identifies TRIM11 as a regulator of EWSR1::ATF1 stability in clear cell sarcoma, showing its depletion leads to metabolic rewiring and cell death, with PCK1 as a potential biomarker.

This study designs gene regulatory networks to slow somatic evolution in simplified multicellular organisms and identifies tradeoffs between network robustness and fitness.

This paper introduces LACO-Stim, a co-stimulatory molecule that enhances CAR-T cell therapy by reprogramming the tumor microenvironment to support endogenous anti-tumor immunity.

The paper identifies a conserved profibrotic transitional state arising from alveolar and airway progenitors in fibrosis and shows its epigenetic regulation.

The paper investigates how intron lariats, especially those with transposable elements, trigger immune responses in cancer cells and shows that RNA editing and DBR1 depletion can be used to enhance anti-tumor effects.

This study evaluates the combination of 5-FU with two triazoloacridinones, C-1305 and TRA-01AR, in CRC, finding that C-1305 shows greater antitumor activity while TRA-01AR has improved tolerability and vascular effects.

This study shows that combining multiple low-dose inhibitors targeting the same oncogenic driver can delay drug resistance in cancer models.

Open-BEATBox enables continuous, autonomous assessment of complex mouse behavior, generating more trials and reducing experimenter workload without adverse effects.

LuCEMe is a luciferase-based method to assess cellular metabolism in various systems, revealing metabolic differences in cancer and immune cell interactions.

This paper introduces [18F]GPR39 2.1, a PET radiotracer for noninvasive imaging of GPR39, showing high specificity and sensitivity in vivo.

This paper develops a PD-1 chimeric switch receptor T-cell platform that improves tumor targeting while reducing toxicity to normal cells in PD-L1-targeted therapies.

This study investigates changes in carotid body mitochondrial function in heart failure, finding decreased oxygen affinity and increased oxidative stress.

This study benchmarks foundation models for resting-state fMRI time series in cognitive aging, finding mixed results on their utility for cognitive assessment and prediction.

This paper demonstrates a drug-free method using laser-induced vapor nanobubbles to create immunogenic whole-cell vaccines for bladder cancer, showing reduced tumor growth and immune activation.

This study shows hypoxia induces LARP1-driven stress granules that protect mRNAs from decay, sustaining mitotic progression in cancer cells.

This study identifies the circadian clock's role in coordinating the Notch-to-Wnt signaling switch to enhance regenerative myogenesis in muscle stem cells.

This paper develops a conductive hydrogel that reduces glial and vascular damage in traumatic brain injury models.

This study identifies the methionine cycle as a driver of mesenchymal traits in PDA, showing that targeting SAHH reduces metastasis and improves survival.

This study evaluates a M4-selective PAM in nonhuman primates, showing broad cognitive and motivational improvements without adverse side effects.

This study shows that a nanotherapy (rPS) that induces islet graft tolerance can be compromised by MRSA infection, but combining it with methylprednisolone improves survival.

This study shows that targeting REV1 in colorectal cancer enhances chemotherapy sensitivity in a context-dependent manner and inhibits organoid growth.

This study identifies TIF1g as a regulator of TGF-b signaling in CD8+ T cells, showing it restricts expansion while preserving cytotoxic function.

The paper investigates how neural circuits in the primate frontal cortex support compositional generalization by separating computations into spatial and temporal components and identifying biases when these components are misaligned.

This study examines sex differences in muscle volume, strength, and motor unit properties during bed rest and retraining in young males and females, finding no sex differences in strength loss but greater MU firing rate reduction in females.

This paper shows that targeting cellular S-acylation with synthetic compounds can spatially disrupt KRAS signaling and stress responses in cancer cells.

This study shows BCL10 gain-of-function mutations prevent naive B cells from entering germinal centers and cooperate with BCL6 to cause extrafollicular diffuse large B-cell lymphoma.