Activation of NLRP3 Inflammasome by Virus-like Particles of Human Polyomaviruses in Macrophages
A. Luciunait?, I. Dalgediene, R. Zilionis, K. Masalaite, A. Sinkunas, M. Norkiene, A. Gedvilaite, I. Kucinskait?-Kodze, A. Zvirbliene
This study shows that spherical virus-like particles from human polyomaviruses activate the NLRP3 inflammasome in macrophages, inducing inflammation and cell death, while filamentous particles do not.
bioRxiv · Nov 15, 2021Immunology