Homogenic endothelium-independent hematopoiesis ensures the abundance of erythrocytes and macrophages during zebrafish development.
R. Elsaid, A. Mikdache, K. Quintero Castillo, Y. Salloum, P. Diabangouaya, G. Gros, C. Feijoo, P. P. Hernandez
The paper shows that early hematopoietic waves in zebrafish embryos are critical for erythrocyte and macrophage abundance during development, with primitive macrophages maintaining tissue regeneration after definitive macrophages are removed.
bioRxiv · Feb 20, 2023 · PreprintImmunology